科研项目:
1.“促进寒地水稻直播发芽出苗有益微生物和活性化合物研究”黑龙江自然科学基金研究团队项目(TD2022C002),2023.01-2026.12,主持人,100万元.
2.“有害生物侵染作物后招募防御微生物的发掘与应用基础研究”国家自然科学基金重点项目(32030090),2021.01-2025.12,主持人,298万元。
3.“新型植物生长调节剂五谷丰素早期应答基因及调控代谢通路研究”国家自然科学基金面上项目(31872037),2019.01-2022.12,主持人,60万元,。
4.“S. avermitilis neau1069全基因组鉴定代谢杀虫剂多拉菌素调控基因及调控机理研究”国家自然科学基金面上项目(31672092),2017.01-2020.12,主持人,65万元。
5.“微生物天然产物农药创制创新团队”农业部农业科研杰出人才及创新团队,2015年。
6.“大豆根内特异微生物及疫霉病菌侵染后根招募微生物代谢活性化合物研究”国家自然科学基金面上项目(31471832),2015.01-2018.12,主持人,92万元。
7.“微生物天然产物农药”国家自然科学杰出青年基金(31225024),2013.01-2016.12,主持人。
8.“Streptomyces avermitilis neau1069生物合成多拉菌素(Doramectin)基因簇克隆和关键基因功能分析”国家自然科学基金面上项目(31071750),2011.01-2013.12,主持人,37万元。
论文著作:
1.Wei-shan Wang , Shan-shan Li , Zi-long Li, Jing-yu Zhang, Ke-qiang Fan, Gao-yi Tan , Guo-min Ai, Sin-Man Lam, Guang-hou Shui, Zhi-heng Yang, Hong-zhong Lu, Pin-jiao Jin, Yi-hong Li, Xiang-yin Chen, Xue-kui Xia, Xue-ting Liu, H. Kathleen Dannelly, Chen Yang, Yi Yang , Si-liang Zhang, Gil Alterovitz,Wen-sheng Xiang*,Li-xin Zhang*. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. Nat Biotechnol. 2020,38(1). IF=68.164生物 一区Top
2.Zhi-yin Yu,Jian-Ping Huang,Jing Yang,Chong-xi Liu,Yi-jun Yan,Li Wang,Jun-wei Zhao,Yin Chen,Wen-sheng Xiang*,Sheng-Xiong Huang*,Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors.Nat. Commun. 2023, DOI:10.1038/s41467-023-35829-1. IF=17.694,综合性期刊 一区Top
3.Chong-xi Liu,Zhi-yan Wang,Yin Chen,Yi-junYan,Lei Li,Yong-Jiang Wang, LuBai,Shan-shan Li,Yan-yan Zhang,Xiang-jing Wang, Sheng-xiong Huang*,Wen-sheng Xiang*.Guvermectin Biosynthesis Revealing the Key Role of a Phosphoribohydrolase and Structural Insight into the Active Glutamate of a Noncanonical Adenine Phosphoribosyltransferase. ACS Chemical Biology. 2023, DOI:10.1021/acschembio.2c00739. IF=4.634,生物 二区
4.Chong-xi Liu, Lu Bai, Peng Cao, Shan-shan Li, Sheng-xiong Huang, Ji-dong Wang, Lei Li, Ji Zhang, Jun-wei Zhao, Jia Song, Peng Sun, Yan-yan Zhang, Hui Zhang, Xiao-wei Guo, Xi-lang Yang, Xin-qiu Tan, Wen-de Liu, Wang, Xiang-jing Xiang*,Wen-sheng Xiang*. Novel Plant Growth Regulator Guvermectin from Plant Growth- Rhizobacteria Boosts Biomass and Grain Yield in Rice.J. Agric. Food Chem.2022, DOI:10.1021/acs.jafc.2c07072.IF=5.895农林科学 一区
5.Chuan-yu Han#, Zhi-yin Yu#, Yu-ting Zhang, Zhi-yan Wang, Jun-wei Zhao, Sheng-Xiong Huang, Zhong-hua Ma, Zi-yue Wen, Chong-xi Liu*,Wen-sheng Xiang*. Discovery of Frenolicin B as Potential Agrochemical Fungicide for Controlling Fusarium Head Blight on Wheat. J. Agric. Food Chem. 2021:69 (7). IF=5.895农林科学 一区
6.Yu-qing Liu, Hai-yan Wang, Shan-shan Li, Yan-yan Zhang, Xu Cheng,Wen-sheng Xiang*, Xiang-jing Wang*. Engineering of primary metabolic pathways for titer improvement of milbemycins in Streptomyces bingchenggensis. Appl Microbiol Biotechnol. 2021 Mar; 105 (5). IF=5.56工程技术 二区
7.Li-yang Chu#, Shan-shan Li#, Zhuo-xu Dong, Yan-yan Zhang, Pin-jiao Jin, Lan Ye, Xiang-jingWang*,Wen-sheng Xiang*. Mining and engineering exporters for titer improvement of macrolide biopesticides in Streptomyces. Microb Biotechnol. 2021 Aug; 15 (4). IF=6.575生物 二区
8.Xiao-yan Yu, Jing Zhang, Xue Zhang, Xi-lang Yang, Xi Xu, Jia-ying Lin, Hui Bing, Xiang-jing Wang, Jun-wei Zhao*,Wen-sheng Xiang*. Identification and Pathogenicity of Fungi Associated with Leaf Spot of Muskmelon in Eastern Shandong Province. China. Plant Dis. 2021 Oct 13. IF=4.614农林科学 二区
9.Xi Xu#, Li Zhang#, Xi-lang Yang, Han-shui Cao, Jing-jing Li, Peng Cao, Li-feng Guo, Xiang-jing Wang, Jun-wei Zhao*,Wen-sheng Xiang*. Alternaria spp. associated with leaf blight of maize in Heilongjiang Province, China. Plant Dis, 2021 Sep 02. IF=4.614农林科学 二区
10.Zhi-yin Yu, Hao Jiang, Li Wang, Feng-Xian Yang, Jian-Ping Huang, Chong-xi Liu, Xiao-wei Guo,Wen-sheng Xiang*,ShengXiong Huang*. Dimeric Pimprinine Alkaloids From Soil-Derived Streptomyces sp. NEAU-C99. Front Chem. 2020 Feb 18;8:95. IF=5.545化学 二区
11.Hai-yan Wang, Xu Cheng, Yu-qing Liu, Shan-shan Li, Yan-yan Zhang, Xiang-jing Wang*,Wen-sheng Xiang*. Improved milbemycin production by engineering two Cytochromes P450 in Streptomyces bingchenggensis. Appl Microbiol Biotechnol. 2020 Apr;104(7). IF=5.56工程技术 二区
12.Pin-jiao Jin, Shan-shan Li, Yan-yan Zhang, Li-yang Chua, Hai-rong He, Zhuo-xu Dong,Wen-sheng Xiang*. Mining and fine-tuning sugar uptake system for titer improvement of milbemycins in Streptomyces bingchenggensis. Synth Syst Biotechnol. 2020 Jul 14;5(3). IF=4.692生物 二区
13.Hui Liu, Yan-yan Zhang, Shan-shan Li, Jia-bin Wang, Xiang-jing Wang*,Wen-sheng Xiang*. Elucidation of the Activation Pathways of ScyA1/ScyR1, an Aco/ArpA-Like System That Regulates the Expression of Nemadectin and Other Secondary Metabolic Biosynthetic Genes. Front Bioeng Biotechnol. 2020 Nov 3;8. IF=6.064工程技术 二区
14.Xiao-wei Guo, Ji-dong Wang, Can Su, Chong-xi Liu, Xiao-yan Ma, Zhi-yin Yu, Jian-song Li, Xiang-jing Wang,Wen-sheng Xiang*, Sheng Xiong Huang*. unique spiro-β-triazinedione-γ-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis. Organic Chemistry Frontiers. 2019(6)18. IF=5.281化学 一区
15.Yue-ming Shan, Chang-long Shu, Kang-lai He, Xue Cheng, Li-li Geng,Wen-sheng Xiang*, and Jie Zhang*. Characterization of a novel insecticidal protein Cry9Cb1 from Bacillus thuringiensis. J Agric Food Chem. 2019 ,67(13). IF=5.895农林科学 一区
16.Chuang Li, Hai-rong He, Jia-bin Wang, Hui Liu, Hai-yan Wang, Ya-jie Zhu, Xiang-jing Wang, Yan-yan Zhang*,Wen-sheng Xiang*. Characterization of a LAL-type regulator NemR in nemadectin biosynthesis and its application for increasing nemadectin production in Streptomyces cyaneogriseus. SCIENCE CHINA (Life Sciences), 2019,62 (3). IF=10.384生物 一区
17.Hai-rong He, Lan Ye, Chuang Li, Hai-yan Wang, Xiao-wei Guo, Xiang-jing Wang, Yan-yan Zhang*,Wen-sheng Xiang*. SbbR/SbbA, an Important ArpA/AfsA-Like System, Regulates Milbemycin Production in Streptomyces bingchenggensis. Front Microbiol. 2018 May 23;9. IF=6.064生物 二区
18.Wei Song, Li-ping Duan, Jun-wei Zhao, Shan-wen Jiang, Xiao-wei Guo,Wen-sheng Xiang*, Xiang-jing Wang*. Kribbella monticola sp. nov., a novel actinomycete isolated from soil. Int J Syst Evol Microbiol. 2018 Nov;68(11). IF=2.689生物 三区
19.Dong-mei Li, Hao Jiang, Li-yuan Han, Yuan-yuan Li, Jun-wei Zhao, Shan-wen Jiang, Xiang-jing Wang*, Wen-sheng Xiang*. Lentzea terrae sp. nov., isolated from soil and an emended description of Lentzea soli. Int J Syst Evol Microbiol. 2018, 68(11). IF=2.689生物 三区
20.Yuan-yuan Tian, Chuan-yu Han, Jun-wei Zhao, Hao-ran Shi, Jiang-mei-hui Hu, Shan-wen Jiang, Xiao-yang Han, Xiang-jing Wang*,Wen-sheng Xiang*. Streptomyces triticisoli sp. nov., a novel actinomycete isolated from rhizosphere soil of wheat (Triticum aestivum L.). Int J Syst Evol Microbiol. 2018,68(10). IF=2.689生物 三区